Are the results of this systematic review valid?

Are the valid results of this systematic review important?

When the odds ratio (OR) < 1
This table applies when a bad outcome is prevented by therapy.

		OR < 1
		0.9	0.8	0.7	0.6	0.5
Patient's expected event rate (PEER)
	0.05	2.09a	104	69	52	41b
	0.10	110	54	36	27	21
	0.20	64	30	20	14	11
	0.30	46	22	14	10	8
	0.40	40	19	12	9	7
	0.50	38	18	11	8	6
	0.70	44	20	13	9	6
	0.90	101c	46	27	18	12d

^aThe relative risk reduction (RRR) here is 10%
^bThe RRR here is 49%
^cFor any OR, NNT is lowest when PEER = 0.50
^dThe RRR here is 9%

When the odds ratio (OR) > 1
This table applies both when a good outcome is increased by therapy and when a side-effect is caused by therapy.

		OR > 1
		1.1	1.2	1.3	1.4	1.5
Patient's expected event rate (PEER)
	0.05	212	106	71	54	43
	0.10	112	57	38	29	23
	0.20	64	33	22	17	14
	0.30	49	25	17	13	11
	0.40	43	23	16	12	10
	0.50	42	22	15	12	10
	0.70	51	27	19	15	13
	0.90	121	66	47	38	32

Can you apply this valid, important evidence from a systematic review in caring for your patient?

Do these results apply to our patient?
Is your patient so different from those in the study that its results cannot apply?
Is the treatment feasible in your setting?
What are your patient's potential benefits and harms from the therapy?
Method I: In the OR tables above, find the intersection of the closest odds ratio from the systematic review and your patient's expected event rate (PEER).
Method II: To calculate the NNT from any OR and PEER:
Are your patient's values and preferences satisfied by the regimen and its consequences?
Do you and you patient have a clear assessment of their values and preferences?
Are they met by this regimen and its consequences?

Should you believe apparent qualitative differences in the efficacy of therapy in some subgroups of patients?-Only if you can say 'yes' to all of the following:

Additional Notes